Endocrine Abstracts

Several studies have pointed to a neural regulation of glucose dependent insulinotropic peptide (GIP) secretion. Bombesin is a neuropeptide found in the amphibian brain and gastrointestinal system – homologous to the C terminus of gastrin-releasing protein (GRP) in mammalians, which displays a wide range of metabolic actions.Aim: Aim of this study was to investigate the effect of intracerebroventicular infusion of bombesin in a centrally mediated re...

Introduction: Autoimmune diabetes mellitus patients, either with Latent Autoimmune Diabetes of Adults (LADA) form or with conventional (juvenile) autoimmune type 1 diabetes (T1D) form, exhibit a higher prevalence of Accompanying Autoimmune Diseases (AADs). The aim of this study was to investigate possible differences in AADs, Familial Autoimmune Diseases (FADs) and metabolic profile between patients with LADA and T1D and between patients with or without anti-GAD (Anti-Glutamic...

Introduction: Insulin-like growth factor-I (IGF-I) has a role in cell proliferation, differentiation, migration, and survival. By alternative splicing different IGF-I mRNA transcripts as IGF-IEc (mechano growth factor, MGF) or IGF-IEa variants are produced. MGF induces muscle hypertrophy and implicated in the pathophysiology of various types of cancer. Aim of the study was to investigate the role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).<p class="ab...

Background: 25 hydroxy vitamin D (25(OH)D) vitamin levels are positively associated with bone mineral density and season, time of day and sun exposure duration influence its synthesis. Variations in daylight throughout the year and zenith angle, depending on the latitude of residence, influence u.v. solar radiation which is closely related to serum 25(OH)D levels. The aim of this study was to investigate the degree of seasonal variation of 25(OH)D serum levels in a population-...

Background and objectives: Medullary thyroid carcinoma (MTC) originates from thyroid C-cells and is a calcitonin (CT) secreting tumour with aggressive behaviour. Surgery is recommended in all patients with basal or calcium-stimulated CT values of 100 pg/ml or higher due to the high probability of MTC. The objective of this study was to investigate the utility of calcium stimulation test for CT in order to distinguish MTC from C-cell Hyperplasia (CCH) preoperatively and to exam...

Introduction: Diagnostic and post-therapy radioiodine whole body scan (WBS) is used in the follow-up of differentiated thyroid carcinoma (DTC) for the detection of local recurrence or remote metastasis. We report a case of false-positive uptake of radioiodine WBS.Case report: A 37-year-old female patient underwent subtotal thyroidectomy for multinodular goitre and histology revealed multifocal papillary thyroid carcinoma, of follicular type with three fo...

Introduction: Acanthosis nigricans is a condition commonly associated with disorders characterised by insulin resistance. Data regarding the treatment of acanthosis nigricans are still insufficient.Case report: A 10-year-old overweight girl (BMI=24 kg/m2) presented at the obesity outpatient clinic. Her family history was negative for metabolic syndrome. Clinical examination revealed extensive acanthosis nigricans involving the neck and armpit....

The management of metastatic differentiated thyroid carcinoma included until recently the use of therapeutic 131I, radiotherapy and in specific cases chemotherapy. However, recently new agents entered in the management of differentiated metastatic thyroid carcinoma which aim at specific cell receptors and inhibit the growth of the carcinoma in a specific and targeted way.The aim was to present the experience of the use of the receptor tyrosine...

Medullary thyroid carcinoma is an uncommon malignancy of hereditary and sporadic presentation. Mutations in the RET-protooncogene are involved in the pathogenesis of >50% of the sporadic cases. Currently, there is no effective treatment for metastatic medullary thyroid carcinoma. The aim was to present a case of metastatic medullary thyroid carcinoma that was treated by the administration of sorafenib, a multiple kinase inhibitor.A patient, female ag...

Well differentiated thyroid carcinoma is associated with prolonged survival in terms of decades and anaplastic carcinoma is associated with survival in months. Intermediate malignancy with a more guarded prognosis is also known to exist.The aim was to describe the case of a patient with a mixed papillary, poorly differentiated and anaplastic thyroid carcinoma.A female patient, aged 73 years presented with a multinodular goiter and ...